RET and colorectal carcinoma: As shown in Fig. 4, in RET-driven (TPC-1, TT, MZ-CRC-1, Lc-2/ad) cells, 1 nM dose of Pz-1 was able to cause a reduction of the percentage of cells in S and G2/M phases and an increase of cells in G0/G1 phase; the maximum effect on cell cycle arrest was achieved at 10 nM.