Pz-1 inhibitory effect had a shorter duration in TPM3-TRKA tumours; thus, TRKA phosphorylation was fully restored after 8 h of treatment with 0.3 mg/Kg Pz-1, and after 12 h of treatment with 1 and 3 mg/Kg when it returned to levels even higher than baseline (Supplementary information, Figure S12). Here, TPM3 is linked to neoplasm.