Of note, when we specifically analyzed the expression levels of genes involved in CGNP differentiation (i.e., ZIC and GRIN genes) across the medulloblastoma cohort, we found that ZIC2, GRIN2A and GRIN2C were relatively high in SHH tumors, even though these tumors clustered mostly to the Intermediate and pCREB Ser133lo/CREBBPlo/EP300lo group (Supplementary Fig. S3). This evidence concerns the gene ZIC1 and medulloblastoma.