We then grouped the medulloblastoma samples into below (or above) average pCREB Ser133 (pCREB Ser133 hi/lo), in combination with below (or above) average CREBBP (CREBBPhi/lo) or EP300 (EP300hi/lo) mRNA levels, and assessed their relationship with overall survival. The gene discussed is CREBBP; the disease is medulloblastoma.