Similar to the tumor compartment, in the spleen, a marked expansion of CD8+ T and NK cells was observed in THOR-707-treated animals, while no significant change in CD4 Treg population was observed (Fig. 5d), resulting in a progressive increase in the splenic CD8+ T/Treg ratio at days 5 and 7 post-dose (Supplementary Fig. 13). The gene discussed is CD4; the disease is neoplasm.