Using the vdb tool to analyze SARS-CoV-2 sequences in the Global Initiative on Sharing Avian Influenza Data (GISAID) dataset11,12, we detected several clusters of sequences distinct from variants B.1.1.7, B.1.351, B.1.1.248, and B.1.4292–5 with spike mutations at sites known to be associated with resistance to antibodies against SARS-CoV-28,13 (Table 1). The gene discussed is CHMP5; the disease is avian influenza.