CREM and hydrops fetalis: ROC curves based on all (15) pairwise differential expression analyses indicated the superior performance of IceR for QE-HF (Fig. 5b, Supplementary Fig. 9f, g) and timsTOF Pro (Fig. 5c, Supplementary Fig. 9h, i) data as evidenced by highly improved AUROC values of 0.95 and 0.96 for the respective instrument.