Interestingly, these treatments also disrupted FcγRIIIB internalization (Fig. 5e) and nAPC generation (Fig. 5f) induced by Ova-IC or SLE-IC, while generation of nAPCs by GM-CSF alone (in presence of soluble Ova control) was unaffected (Fig. 5f). This evidence concerns the gene CSF2 and systemic lupus erythematosus.