Tumor growth in 3G8-fOva-immunized mice expressing FcγRIIIB and FcγRIIA was significantly reduced compared to unimmunized, GM-CSF treated humanized mice (Fig. 7a, Supplementary Fig. 7a) and two additional sets of GM-CSF treated controls: Wild-type mice given fOva, which will lead to an anti-tumor immune response driven by endogenous APCs, such as cDCs, and γ−/− mice given 3G8-fOva that do not make nAPCs as they lack the FcγRIIIB but nonetheless, like wild-type plus fOva, will mount an immune response to fOva (contained in the 3G8-fOva conjugate) (Fig. 7a). The gene discussed is CSF2; the disease is neoplasm.