Since GM-CSF alone promotes expression of DC-like markers on neutrophils, we investigated whether FcγR engagement induced a gene program distinct from that of GM-CSF by analyzing bulk RNA-seq data obtained from nAPCs generated in vitro with Ova- or Ova-IC (in the presence of GM-CSF), or SLE-IC alone. This evidence concerns the gene CSF2 and systemic lupus erythematosus.