SLE-IC did not promote nAPC conversion of γ−/− neutrophils lacking activating FcγRs, whereas neutrophils from FcγR humanized mice expressing either human FcγRIIA or FcγRIIIB31 yielded nAPCs in numbers comparable to wild-type neutrophils (Fig. 1e). Here, FCGR2A is linked to systemic lupus erythematosus.