Secondary screening confirmed the enhanced sensitivity of RIT1-mutant cells to depletion of USP9X and AURKA (Supplementary Fig. 3g, Supplementary Fig. 4a, b) along with the RAS pathway and Noonan syndrome genes SHOC2 and SOS1 (Supplementary Fig. 3g, Supplementary Fig. 4a, b). The gene discussed is SOS1; the disease is Noonan syndrome.