Secondary screening confirmed the enhanced sensitivity of RIT1-mutant cells to depletion of USP9X and AURKA (Supplementary Fig. 3g, Supplementary Fig. 4a, b) along with the RAS pathway and Noonan syndrome genes SHOC2 and SOS1 (Supplementary Fig. 3g, Supplementary Fig. 4a, b). This evidence concerns the gene AURKA and Noonan syndrome.