Supplementation of FFA results in augmented expansion of CD8+T cells.53 Although the combination of C75 with CYH33 failed to inhibit the proliferation of 4T1 cells in vitro, this combination synergistically inhibited the growth of 4T1 allografts in vivo, which was accompanied by enhanced level of FFAs and improved infiltration of CD8+T cells in the tumor tissue. This evidence concerns the gene CD8A and neoplasm.