Furthermore, increased SNHG12 not only regulates malignant behavior by activating oncogenes (AMOT, HuR slug/ZEB2) [15, 35], signaling pathways (MAPK/Slug, wnt/β-catenin, and Notch signaling pathway) [13, 14, 10, 34, 36], and the microRNA-gene axis (miR-125b/STAT3 and miR-101-3p/FOXP1) [33, 31, 37] but also enhances chemoresistance of tumor cells [31, 32]. This evidence concerns the gene SNAI2 and neoplasm.