Yin et al., Zhao et al., and Long et al. found that SNHG12 regulates brain microvascular endothelial cell death, the inflammatory response, and angiogenesis during and after ischemic stroke through target genes and signaling pathways (Sirt1, AMPK signaling pathway, and miR-150/VEGF pathway) [38–40]. The gene discussed is SIRT1; the disease is ischemic stroke.