Elimination of CD20+B cells with CD4+/CD8+ T reserved showed inhibition effects on liver cancer progression in Mdr2−/− mice under liver fibrosis condition [90], while clinical studies revealed that B cells were notably decreased in HCC, and the density of tumor infiltrating CD20+B cells was positively correlated with superior survival as well as CD3+T cells [91, 92]. Here, CD4 is linked to hepatocellular carcinoma.