A-fetoprotein (AFP) specific CD8+ T cell clusters, deprived from human leukocyte antigen (HLA)-A2 transgenic AAD mice, were hybridized to generate CD8+ T cell with HLA-A2/AFP identifiable TCR, and the hybridoma T cell clones were detected to have effective toxicity on HCC tumor cells [66]. This evidence concerns the gene CD8A and neoplasm.