TNF and hepatocellular carcinoma: Currently, Tregs blunt antitumor immunity via immune cell correlated intervening approaches in PLC (Fig. 2): 1) APC suppression: Tregs harvested from HCC mice inhibit DC function by down-regulating the co-stimulator CD80/86 via CTLA-4 expression, secreting inhibitory cytokines such as IL-10 to weaken DC maturation and the tumor necrosis factor-α (TNF-α)/IL-12 production, and inhibiting via cell to cell contacts [41].