In AC220-treated mice, we noticed a gain in BM CD31+Sca-1high ECs and vessels (i.e., arterioles) (Fig. 5d, e), an increase of Gata2 levels in ECs (Fig. 5f) but not in LSKs (Additional file 1: Fig. S12a), an increase of miR-126 levels in both ECs and LSCs (i.e., AML LSK; Fig. 5g, Additional file 1: Fig. S12b), and a higher frequency of quiescent LSK cells (LSKG0, Fig. 5h; Additional file 1: Fig. S12c) compared with vehicle-treated controls. Here, PECAM1 is linked to acute myeloid leukemia.