Accordingly, normal wt mice engrafted with BM MNCs from MllPTD/WT/Flt3ITD/ITD AML donors had higher levels of BM TNFα (Additional file 1: Fig. S7d) and reduced levels of BM EC miR-126 (Additional file 1: Fig. S10f), in addition to a decrease in CD31+Sca-1high ECs and arterioles (Fig. 1c, d; Additional file 1: Fig. S2e), compared with mice engrafted with BM MNCs from normal wt donors. This evidence concerns the gene TNF and acute myeloid leukemia.