Aberrant transcription factors encoded by AML-related rearrangements such as AML1-ETO (RUNX1-CBFA2T1), PML-RARα, and ZBTB16 (PLZF)-RARα have been reported to induce Wnt signaling, leading eventually to the upregulation of MYC [638–640]. The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.