BCR-ABL1-mediated activation of JAK2 and STAT5 in both CML and Ph-positive B-ALL can sustain elevated MYC levels through promoting its gene expression and guarding MYC against ubiquitination and proteasome-dependent degradation (Fig. 7) [454, 455]. The gene discussed is MYC; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.