Despite genetic aberrations in the MYC gene, the MYC hyperactivation in transformed CLL could be as a result of miR-17-92 cluster activity [521], mutations or deletions of MYC regulator MGA [522], and NOTCH1 gene [523], CD40L activation of NF-kβ [524] or BCR (B-cell receptor) signaling [525]. This evidence concerns the gene CD40LG and B-cell chronic lymphocytic leukemia.