Overexpression of HDACs such as HDAC9 and SIRT1 have an adverse prognosis in MLL-rearranged lymphoblastic leukemia [499], noteworthy, the latter alters the acetylation of critical genes including TP53, MYC, and NF-kβ, causing drug resistance [28, 499–503]. The gene discussed is MYC; the disease is acute lymphoblastic leukemia.