It was found (Fig. 7A, B) that compared with sh-NC + oe-NC group, the volume and weight of transplanted tumor in sh-ELK4 + oe-NC group were reduced; compared with sh-ELK4 + oe-NC group, the tumor volume and weight were increased in sh-ELK4 + oe-KSR1 group. The gene discussed is ELK4; the disease is neoplasm.