In addition, different tumors may activate different downstream genes through the same miRNA molecule, for example, in ccRCC, by sponging miR-338-3p and upregulating ETS1 expression or in NSCLC via activating ADAM17, thus promoting tumor proliferation, invasion and metastasis, which is due to the functional characteristics of miRNAs capable of regulating multiple downstream genes. Here, ADAM17 is linked to nonpapillary renal cell carcinoma.