This paper reviews SBF2-AS1 regulation of tumor cell proliferation, metastasis, invasion, angiogenesis, chemoresistance, radiosensitivity, and the cell cycle through interactions with different molecules (miRNA, DNA or signaling pathway molecules), indicating that SBF2-AS1 has promise in the future as a diagnostic and prognostic biomarker and a prospective therapeutic target for cancers. The gene discussed is SBF2; the disease is cancer.