BIRC5 and neoplasm: As shown in Fig. 2H, the content of BIRC5 in the cells was found to be the lowest in the NPs group, and the above results indicated that Fe3O4 MNPs effectively and simultaneously delivered AS-ODN and siBIRC5 to lung adenocarcinoma tumor cells, to reduce the BIRC5 expression in tumor cells via co-inhibition.