Similarly, in #1 primary CML cells wogonin reduced the expression of RNA Pol II and its phosphorylation form (RNA Pol II Ser2 and Ser5), the level of CDK9 had slight increased by treatment with 80 μM wogonin (Fig. 2a). Here, CDK9 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.