For dichotomous laboratory markers, higher levels of C-reactive protein (CRP), lactate dehydrogenase (LDH), serum amyloid A, fibrinogen (FIB), D-dimer, adenosine deaminase, reduced haemoglobin, and lower levels of lymphocyte, eosinophil, platelet counts, calcium, phosphorus, albumin (ALB), albumin/globulin, prealbumin, total cholesterol, high density lipoprotein cholesterol, retinol binding protein, apolipoprotein A1, SaO2, PaO2/FiO2 increased the risk of elevated COVID-19 severity (all P values < 0.05). This evidence concerns the gene ALB and COVID-19.