In addition, compared to participants with 0 or 1 determinant, the pooled adjusted OR for a combination of ≥2 of the three significant determinants (iron deficiency, low eGFR and high CRP) on the presence of anaemia was 4.53 (95% CI, 2.66 to 7.72, I2 = 50%). This evidence concerns the gene CRP and anemia (phenotype).