However, for the association between eNOS rs1799983 polymorphism with hypertension under allelic model (T vs G), recessive model (TT vs GG + GT), and overdominant model (GT vs GG + TT), the Z-curve crossed trial sequential monitoring boundary, and the sample sizes were also more than the RIS (Fig. 3A, E, F). This evidence concerns the gene NOS3 and hypertensive disorder.