To generate the model for assessing the risk of AKI, a total of 35 potential predictors were contained in the LASSO regression, allowing to select nine best predictors: age, male gender, LVEF, hypertension, hemoglobin, uric acid, hypomagnesemia, and oral non-steroidal anti-inflammatory drug (NSAID) and renin-angiotensin system inhibitor (Figure 2). This evidence concerns the gene REN and acute kidney injury.