GAPDH and familial pancreatic carcinoma: For example, methylation of GAPDH is associated with its enhanced catalytic activity in pancreatic cancer [87]; acetylation alters the activity and stability of pyruvate kinase M in cancer [88]; acetylation regulates the stability of actin filaments and microtubules, hence intracellular transport [2], including of the IAV components [18]; and, finally, methylation regulates the mRNA splicing [75,76].