CGAS and neoplasm: Further in silico analysis revealed seven of 32 TCGA tumor types (bladder urothelial carcinoma, breast invasive carcinoma, colon adenocarcinoma, head and neck squamous cell carcinoma, lung adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma) have significantly increased promoter methylation in either cGAS or STING as compared to matched normal tissue [33].