PROS1 and infection: Infection of target cells with DENV results in the production of three viral structural proteins (capsid, C; pre-membrane, prM; and envelope, E) that are required for virion formation, and seven viral nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5) that play important roles in viral polyprotein processing and viral RNA replication [10].