MAPK8 and infection: Infection with DENV has been demonstrated to induce the activation of intracellular signaling proteins in the mitogen-activated protein kinase (MAPK) pathways, including the two extracellular signal-regulated kinases (ERK1/2), the Jun N-terminal kinase (JNK), and p38—all of which participate in viral replication and pathogenesis [44,45].