These issues further interrogate whether the circulating native sACE2 could exert a protection against angiotensin II mediated cardiac dysfunction or could it effectively bind to SARS-CoV-2 spike protein as the patients with comorbid conditions, including heart failure or CAD are more vulnerable to the SARS-CoV-2 mediated severity, despite elevated sACE2 levels in their circulation. Here, AGT is linked to heart failure.