ACE2 and COVID-19: In fact, a comparative analysis from autopsy lungs taken from both COVID-19 and influenza infected patients have shown (i) unique vascular features with severe endothelial injury; (ii) EC infected SARS-CoV-2 virus with disrupted cell membrane; (iii) increased ACE2 positive ECs; (iv) EC swelling, disrupted intercellular junctions and loss of contact with the basal membrane, which were noticed among COVID-19 patients.