The 2017 APASL guidelines [24] recommend abdominal ultrasounds with AFP every 6 months for HCC screening in patients with CHB cirrhosis in Asian females > 50 years, Asian males > 40 years, patients of African background > 20 years, and in patients with a family history of HCC (no specific starting age recommended) (Table 1). The gene discussed is AFP; the disease is Cirrhosis.