Interestingly, in the case of JUNV Candid#1, despite the differences in IFN-β mRNA levels in infected A549/Scr and A549/PKR KO cells, viral progeny production was not affected [14], suggesting that either the contribution of PKR against JUNV infection is not biologically relevant or that JUNV can deploy molecular mechanisms to overcome the host’s innate immune response. The gene discussed is IFNB1; the disease is infection.