In contrast, recent findings suggest that the inflammatory markers (i.e., hs-C reactive protein (CRP), interleukin (IL)-1Ra, IL-6, tumor necrosis factor (TNF)-alpha and adiponectin), although highly associated with obesity, do not predict—in linear regression models—weight gain in an adult population. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.