AKT1 and cancer: In summary, A. canaliculatum, A. orientalis, AA, and AB23A might regulate MMP activity and chemokine production in highly invasive cancer cells, such as SK-HEP-1, HEY, and MDA-MB-231, by hindering molecular downstream pathways, such as PI3K/AKT/mTOR and NFκB which activations trigger metastatic progression.