INSR and polycystic ovary syndrome: The various clinical symptoms of the disease indicate that many metabolic pathways participate in PCOS development, including: secretion and activity of insulin, with genes encoding for insulin receptor (IR), insulin (INS), and insulin-like growth factor (IGF) and its receptor; genes encoding for steroidogenesis; genes responsible for the activity of cytochrome P450 (CYP 17, CYP 11 alpha); and other metabolic and hormonal pathways, with genes for androgenic receptor (AR), LH receptor, leptin, and follistatin [10].