The novelty of the present study lies in the fact that we analyzed the JRE of TAS1R2, TAS1R3, TAS2R14 and TAS2R38 in a well-characterized cohort of women with MO according to the presence or absence of MetS, and according to the presence of NAFLD. This evidence concerns the gene TAS1R2 and metabolic dysfunction-associated steatotic liver disease.