On the other hand, decreased methylation of tumor-related genes such as PPAR-gamma, E-cadherin, matrix metalloproteinase-2 (MMP2), cyclooxygenase-2 (COX-2) or phosphatase and tensin homolog deletion on chromosome 10 (PTEN) was observed after PUFAs treatment of CRC cells [122]. The gene discussed is MMP2; the disease is colorectal carcinoma.