SIRT1, along with histone deacetylation, regulates transcription factors, such as p53 [148], and DNA repair proteins, such as poly ADP-ribose polymerase 1 (PARP1) [149] being a protection from a wide array of metabolic and age-related diseases, such as cancer, cardiovascular and neurodegenerative diseases. The gene discussed is PARP1; the disease is neurodegenerative disease.