The role of CREBBP in CRC tumorigenesis is not clear, however CREBBP expression was correlated with improved-long term outcomes in patients after primary resection of the tumor (mesorectal excision—TME and partial mesorectal excision—PME), followed by adjuvant chemotherapy (oxaliplatin, folinic acid and 5-fluorouracil) [184]. This evidence concerns the gene CREBBP and colorectal carcinoma.