It was found by Arthur et al. [74] that colitis-susceptible interleukin-10 (IL-10) deficient mice infected with E. coli NC101 had decreased number of microorganisms and microbial diversity indicating a putative difference in the gut microbiota between sick and healthy individuals and more often developed invasive CRC after azoxymethane (AMO) treatment. Here, IL10 is linked to colitis.