In addition, it was shown that FadA modulates Wnt/ß-catenin signaling pathway by activation of Annexin-1 (ANXA1) expression through E-cadherin, and ANXA1 expression is increased only in proliferating CRC cells, but not in non-proliferating and non-cancerous cells [79]. The gene discussed is CDH1; the disease is colorectal carcinoma.