Hsu et al. [103] assessed the effect of maternal resveratrol intake of obese rats and found that resveratrol treatment restored adiponectin, AKT phosphorylation, and brain-derived neurotrophic factor (BDNF) in male fetal brain, increased blood pressure, and reduced increased body weight and peripheral insulin resistance in adult male offspring, further demonstrating that intervention with this polyphenol may protect offspring against HFD-induced obesity. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.