Several in vitro studies have demonstrated that resveratrol has an anti-obesity effect by negatively regulating white adipogenesis via inhibiting PPARγ and C/EBPα [66], activating Sirtuin 1 (SIRT1) and (PPARγ Coactivator 1) PGC1α [67], attenuating white adipogenesis and lipid accumulation. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.