A DM state has been shown to be associated with sarcopenia via several different mechanisms, including malnutrition, insulin/IGF-1 deficiency, and a sustained hyperglycemia condition, while it has been speculated that sarcopenia might exacerbate the DM condition because of reduced muscle tissue, against which insulin treatment protects by stimulating transport plasma glucose into muscle tissue. The gene discussed is IGF1; the disease is sarcopenia.