Interestingly, since conducting the HATFF study, studies with human aortal endothelial cells and periodontal ligand fibroblasts in primary culture and model hyperglycemia have indicated that tRES-HESP may correct endothelial dysfunction and periodontal ligament dysfunction associated with hyperglycemia in prediabetes and diabetes [9,10]. This evidence concerns the gene TMPRSS11A and diabetes mellitus.