APP and Mental deterioration: This neurodegenerative disorder, which leads to cognitive decline, is characterized by aberrant amyloid precursor protein (APP) processing, the deposition of β-amyloid (Aβ) peptides such as Aβ40 and Aβ42, and the aggregation of hyperphosphorylated tau (p-tau) protein, all processes that are accompanied by neuronal loss [2].