For instance, combination of T3 and gemcitabine was reported to down-regulate NF-Kβ activity along with NF-Kβ regulated gene products, such as cyclin D1, c-Myc, VEGF, MMP-9, and CXCR4 in pancreatic cancer [58]. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.