It has been separately tested in neovascular age-related macular degeneration patients, in combination with ranibizumab (EMERGE phase 2 clinical trial) [96] and with aflibercept (DECO phase 2 clinical trial) (NCT03452527), showing further improvement of neovascularization regression, compared with anti-VEGF injections alone. Here, VEGFA is linked to age-related macular degeneration.