This signal involves a complex integrated by receptor-interacting serine/threonine protein kinase 1 (RIPK19), tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2), and TNF receptor-associated death domain (TRADD), activating pro-tumor pathways, such as IkB/NF-kB, MAPK/ERK, STAT3, PI3K, Akt, JAK2, and Src [10]. This evidence concerns the gene TNF and neoplasm.