MAPT and Alzheimer disease: The AD mouse models we used were (i) APP23 mice, which express a Swedish mutant form of APP and are characterized by amyloid plaque formation and memory impairment [56,57], and either (ii) pR5 mice, which express the P301L mutant form of Tau found in FTLD-Tau, a strain with tangle formation and memory impairment [58,59], or (iii) K3 mice, which express the K369I mutant form of Tau found in FTLD-Tau, a strain with tangle formation and memory impairment and aspects of Parkinsonism [60].