CTSB and colonic neoplasm: For an aspect of anti-cancer properties, it has reported that Zingipain, which is a cysteine protease isolated and purified from Zingiber ottensii rhizomes, possessed relatively strong anti-proliferative effects against cancer cell lines including hepatocellular carcinoma, HEP-G2 (IC50 = 1.13 μg/mL), and colon cancer, SW620 (IC50 = 5.37 μg/mL) [15].