ESR1 and neoplasm: In univariable analyses, tumor size, nodal status, ESR1 mRNA expression, PGR mRNA expression, ERBB2 mRNA expression, MKi67 mRNA expression, ERVentana expression central, PRVentana expression central, HER2Ventana+ISH central, and Ki67Ventana expression central were significantly associated with time to DR (Figure 1B, D, F, H; Supplementary Figure S2, available at https://doi.org/10.1016/j.esmoop.2021.100228 and Table 4).