ANGPTL3 and hypertriglyceridemia: The increase in HDL-C in CETP tg, LDLr−/− mice treated with Angptl3 ASO demonstrates that in the setting of neutral lipid transfer protein, CETP, and hypertriglyceridemia, the Angptl3 ASO–mediated reductions in TG can limit the amount of VLDL-TG available for exchange for HDL-cholesteryl ester.