Besides, CARD11 expression had a significantly positive correlation with T cells CD8+, T cells CD4+ naïve, and T cells follicular helper, which indicated that CARD11 expression was closely related to T cells subtypes, and had a closely negative correlation with mast cells, which played a protective role in tumor, but also had the ability to promote angiogenesis and tumor progression [35]. This evidence concerns the gene CD8A and neoplasm.