We have previously reported that, in an African American population, both the HLA-DRB1*15:01 and the HLA-DRB1*15:03 alleles (in the absence of the HLA-DQB1*06:02 allele) are associated with an increase in MS risk whereas the HLA-DQB1*06:02 allele (in the absence of the HLA-DRB1*15 alleles) is not [32]. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.