In addition, DPP4 inhibited erastin-induced ferroptosis in colorectal cancer after its activity was blocked by p53. However, in the absence of p53, DPP4 combines with NOX1 to form the NOX-DPP4 complex, thereby leading to plasma membrane lipid peroxidation and ferroptosis [21, 34]. This evidence concerns the gene NOX1 and colorectal cancer.