Notably, the results showed that overexpression of NCOA4 was associated with renal cell carcinoma, the JAK-STAT pathway, Toll-like pathway and the NOD-like receptor pathway (|NES|> 1, p < 0.05, FDR < 0.25, Supplementary Figure 3A–3D). The gene discussed is SOAT1; the disease is hereditary clear cell renal cell carcinoma.