VEGFA and ulcer disease: Although it has been revealed that miR-205-5p suppresses VEGFA expression at the post-transcriptional level in mesenchymal stem cells (MSCs), inhibition of which can significantly improve the therapeutic effect of MSCs on diabetic wounds by further promoting vascularization [21], this is the first study to identify the increased level of this antiangiogenic miRNA in the local wound of DF ulcers encapsulated in EVs, which could effectively protect cargo miRNAs from degradation and transfer into recipient cells.