The lower PROMIS‐PI scores in LGI1 antibody patients were sustained at latest (median = 5 years) follow‐up (p = 0.025, Fig 2C) and, at this time point, CASPR2 antibody patients lower overall self‐reported health (p = 0.019), with greater concerns in the domains of mobility (p = 0.014), usual activities (p = 0.019), and anxiety/ depression (p = 0.043, Fig 2D). This evidence concerns the gene LGI1 and major depressive disorder.