Among common oral inflammatory conditions, the presence of epigenetic modifications in proinflammatory cytokines such as Fas-associated death domain protein (FADD), interleukin-12 subunit beta (IL-12B), and interleukin-4 receptor (IL-4R) has been associated with periodontal disease (Schulz et al. 2016). This evidence concerns the gene IL12B and periodontal disorder.