In both humans and mice, the UBE3A-ATS transcript originates from the same precursor encoding small nuclear ribonucleoprotein N (SNRPN), which has multiple upstream promoters in the Prader-Willi syndrome imprinting center (PWS-IC) and upstream of the U exons where it initiates, and it ultimately overlaps with the UBE3A gene (Figure 1A) (9). The gene discussed is UBE3A; the disease is Prader-Willi syndrome.