APOE and familial dilated cardiomyopathy: B6.Cg-Apoeem2(APOE*)Adiuj/J (human ApoE3–knockin) and B6(SJL)-Apoetm1.1(APOE*4)Adiuj/J (human ApoE4–knockin) mice were randomly and blindly assigned into DCM or sham experimental groups (E3-DCM, n = 20; E3-Sham, n = 15; E4-DCM, n = 21; E4-Sham, n = 16; Table 3) and sacrifice time points (immediately after 6 weeks of DCM [controls who received no decompression], 24 hours, 72 hours, 3 weeks, and 5 weeks postdecompression or postlaminectomy; Figure 2).